PRENOMON

General project data

• Description: Development of a system of preservation of organs for transplantation capable of maintaining the organ in functional conditions during the preservation process. From this not only the objective of preserving the organ in its original form, but also the conditions, but also to monitor the metabolic parameters of the during the preservation process, to regulate the values of the and determine its post-transplant viability. CHALLENGES-COLLABORATION 2016.
• File number: RTC-2016-5108-1.
• Date of grant: 08/03/2016.
• Execution dates: 31/12/2019.

Presentation and objectives

Transplantation is the best technique available for the treatment of terminal failure of most of the essential organs, with the majority of the benefited more than 1 million patients worldwide in the past. transplantation of an organ. Spain has been the world leader for the past 22 years in terms of the number of transplants per capita that are performed annually. However, despite to the clinical success of organ transplantation, the current demand for organ far exceeds the supply of donors. According to the World Registry of Transplants, the approximately 115,000 transplants performed in 2013. only covered 10% of the world’s needs. Mortality rates while awaiting transplantation are found to be in the range of 15-30%, and in some reports in the range of 15-30% in function of the organ in question. In this regard, the development of new preservation systems, evaluation and treatment of organs for transplantation takes on an important role in the preservation methods based on the use of the traditional method of preservation. cold storage lacks the necessary capacity to valorize these organs. Therefore, the introduction of new systems of preservation will be essential for the development of the organ transplantation in the coming years. The main objective of this project is the development of a system of preservation of organs for transplantation capable of maintaining the organ in functional conditions during the preservation process. To this end, The system shall be capable of maintaining the conditions of and to supply the organ with oxygen and nutrients. nutrients necessary for its functioning. The PRENOMON project will be valid for the preservation of kidney and liver and focuses on two basic developments:

1. On the one hand, the device capable of providing the conditions for preservation, which does not come into contact with the organ.
2. On the other hand, the components that come into contact with the organ or perfusion medium.

In order to achieve the main objective, it will be necessary to achieve the following secondary objectives:

1. Development of a system capable of providing the conditions for temperature, flow rate, pressure, etc., that simulate the physiological state that the organ experiences in-vivo.
2. Development of a software capable of controlling with precision parameters, as well as the proper management of the interaction with the user.
3. Development of on-line sensors capable of providing real-time measurements of the metabolic parameters of the organ.
4. Development of a disposable perfusion circuit, containing the elements necessary to direct the perfusion medium into the organ, as well as the chamber to keep the organ in good condition. and temperature.

Participating entities

The MODCOMP project has 17 partners from different countries. European countries: Spain, the United Kingdom, Portugal, Italy, Greece, Belgium and Sweden. Among them, those who collaborate with ITAINNOVA in the field of computer simulation are:

• EBERS Medical Technology, S.L. (Project leader).
• BEONCHIP, S.L.
• AITIIP FOUNDATION.
• University of Zaragoza.
• Instituto Tecnológico de Aragón, ITAINNOVA (Spain).

Call for applications

State Program for Research, Development and Innovation Oriented towards the Challenges of Society, within the framework of the State Plan of Research Scientific and Technical and Innovation 2013-2016.

Budget

• Total bankable budget of the project: 691,482.27 .
• ITAINNOVA’s bankable budget: 68,120.50 .

Financing

• Total project grant: 131,472.76 .
• Total project loan: 431,793.23 .
• Grant to ITAINNOVA: 68,120.50 .

This project has been co-funded by the Ministry of Economy, Industry and Competitiveness, within the State Program for Research, Development and Innovation Oriented to the Challenges of Society, in the framework of the State Plan for Scientific and Technical Research and Innovation 2013-2016.